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Core competencies for postdoctoral fellows and young scientists

An academic career can have very diverse goals, which can be pursued individually depending on one's interests. To obtain a university professorship, both a strong interest in research and a passion for teaching are prerequisites for achieving this career goal. In addition to the professional requirements, the young scientists should also have additional key qualifications that support their everyday research work.

The Faculty attaches particular importance to the continuous training of young scientists and the qualified supervision of doctoral candidates. Applicants for admission to habilitation must provide evidence of at least four continuing education courses on core competencies for young scientists and university teachers. Participation in further training to ensure good scientific practice is mandatory.

β-Turn mimetic synthetic peptides as amyloid-β aggregation inhibitors

Stefanie Deike, Sven Rothemund, Bruno Voigt, Suman Samantray, Birgit Strodel, Wolfgang Binder

Highlights:

Artificially modified amyloid Aβ40 – proteins are studied as a model system.

Synthetic beta-turn mimetic are conjugated into the turn region of Aβ40.

Both acceleration and retardation of fibrillation were observed.

Conformationally constrained turns reduce fibrillation, also in mixture with native Aβ40.

Conformationally flexible beta-turn-mimics lead to enhanced fibrillation.

Structural downsizing yields the modified Aβ16-35 as inhibitor of the aggregation of Aβ40.

https://doi.org/10.1016/j.bioorg.2020.104012

 

Kategorie/n: TC Strodel

β-Turn mimetic synthetic peptides as amyloid-β aggregation inhibitors

Stefanie Deike, Sven Rothemund, Bruno Voigt, Suman Samantray, Birgit Strodel, Wolfgang Binder

Highlights:

Artificially modified amyloid Aβ40 – proteins are studied as a model system.

Synthetic beta-turn mimetic are conjugated into the turn region of Aβ40.

Both acceleration and retardation of fibrillation were observed.

Conformationally constrained turns reduce fibrillation, also in mixture with native Aβ40.

Conformationally flexible beta-turn-mimics lead to enhanced fibrillation.

Structural downsizing yields the modified Aβ16-35 as inhibitor of the aggregation of Aβ40.

https://doi.org/10.1016/j.bioorg.2020.104012

 

Kategorie/n: TC Strodel

β-Turn mimetic synthetic peptides as amyloid-β aggregation inhibitors

Stefanie Deike, Sven Rothemund, Bruno Voigt, Suman Samantray, Birgit Strodel, Wolfgang Binder

Highlights:

Artificially modified amyloid Aβ40 – proteins are studied as a model system.

Synthetic beta-turn mimetic are conjugated into the turn region of Aβ40.

Both acceleration and retardation of fibrillation were observed.

Conformationally constrained turns reduce fibrillation, also in mixture with native Aβ40.

Conformationally flexible beta-turn-mimics lead to enhanced fibrillation.

Structural downsizing yields the modified Aβ16-35 as inhibitor of the aggregation of Aβ40.

https://doi.org/10.1016/j.bioorg.2020.104012

 

Kategorie/n: TC Strodel

β-Turn mimetic synthetic peptides as amyloid-β aggregation inhibitors

Stefanie Deike, Sven Rothemund, Bruno Voigt, Suman Samantray, Birgit Strodel, Wolfgang Binder

Highlights:

Artificially modified amyloid Aβ40 – proteins are studied as a model system.

Synthetic beta-turn mimetic are conjugated into the turn region of Aβ40.

Both acceleration and retardation of fibrillation were observed.

Conformationally constrained turns reduce fibrillation, also in mixture with native Aβ40.

Conformationally flexible beta-turn-mimics lead to enhanced fibrillation.

Structural downsizing yields the modified Aβ16-35 as inhibitor of the aggregation of Aβ40.

https://doi.org/10.1016/j.bioorg.2020.104012

 

Kategorie/n: TC Strodel
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