Stefanie Deike, Sven Rothemund, Bruno Voigt, Suman Samantray, Birgit Strodel, Wolfgang Binder
Highlights:
Artificially modified amyloid Aβ40 – proteins are studied as a model system.
Synthetic beta-turn mimetic are conjugated into the turn region of Aβ40.
Both acceleration and retardation of fibrillation were observed.
Conformationally constrained turns reduce fibrillation, also in mixture with native Aβ40.
Conformationally flexible beta-turn-mimics lead to enhanced fibrillation.
Structural downsizing yields the modified Aβ16-35 as inhibitor of the aggregation of Aβ40.
https://doi.org/10.1016/j.bioorg.2020.104012