| 1907 | Opening of the Municipal Hospitals and the Academy for Practical Medicine |
| 1912 | Foundation of the Municipal Sisterhood of the Red Cross |
| 1919 | Commencement of clinical teaching |
| 1923 | Foundation of the Medical Academy, takeover of the West German Maxillofacial Clinic into the Medical Academy |
| 1931 | Establishment of the Dentistry degree programme |
| 1933/35 | Expulsion of Jewish staff during National Socialism |
| 1935 | Independent right to award doctorates |
| 1943/45 | Bomb damage during the Second World War |
| 1945 | Closure and reopening of the Medical Academy by the Allies |
| 1945/53 | Reconstruction and denazification |
| 1958 | Move into the new building for surgery |
| 1965 | Foundation of the University of Düsseldorf |
| 1966 | Establishment of the Faculties of Medicine and Natural Sciences and Philosophy |
| 1968 | Establishment of the first Collaborative Research Centre CRC 30 Cardiology |
| 1973 | Takeover of the Municipal Hospitals as medical institutions of the University of Düsseldorf by the State of NRW |
| 1985 | Opening of the MNR Clinic |
| 1995 | Opening of the Schlossmannhaus (Centre for Paediatrics and Adolescent Medicine) |
| 2001 | Foundation of the University Hospital Düsseldorf as an institution under public law |
| 2011 | Opening of the new medical library O.A.S.E |
| 2013 | Establishment of the model study programme in human medicine |
| 2014 | Opening of the Centre for Operative Medicine II |
| 2018 | Completion of the Medical Research Centre II |
