CRC in cooperation with the University Hospital Essen, the German Diabetes Center (DDZ), the Leibniz-Institut für umweltmedizinische Forschung (IUF).
Spokesperson: Prof. Dr. Fischer, HHU. Duration: since 2015.
CRC 991 investigated the structure of representations in language, cognition and science. Linguistic and philosophical research was combined with empirical studies from neuroscience and psychology.
Spokesperson: Prof. Dr. Laura Kallmeyer, HHU
Duration: from 2011 to 2020
Liver diseases are often chronic and systemically relevant, as they can affect the function of other organ systems (e.g. kidney, brain, intestine, cardiovascular system, blood, endocrine system, immune system). Conversely, other organ systems also influence liver function.
Such system influences not only affect the extent and course of liver damage, but also the regeneration processes in the liver that are simultaneously triggered with each liver damage. The remarkable ability of the liver to regenerate serves to maintain vital liver functions and occurs not only after partial hepatectomy, but also in response to the most diverse forms of liver damage.
Spokesperson: Prof. Dr. Dieter Häussinger, HHU
Duration: 2012 to 2019
The central question of all subprojects of the CRC 590 was to analyse and understand those processes that lead to the formation of the different characteristics of cells, such as skin, nerve or muscle cells. The common goal of all projects was to gain a better insight into the diverse genetic, molecular and cellular bases of the formation of cell type-specific characteristics.
These processes for the formation of different cell characteristics take place during the development of multicellular organisms, whereby the information about the temporal and spatial sequence is stored in the genetic material of the cells (inherent processes). However, the fully formed (differentiated) cell is also able to react to changed environmental conditions (e.g. light) or to react after injury or attack by parasites in such a way that it can survive (adaptive processes).
Spokesperson: Prof. Dr. Peter Westhoff
Institute of Developmental and Molecular Biology of Plants
Duration: 2001 to 2012
Cardiovascular diseases are the result of a complex interaction between genetic susceptibility and a variety of environmental factors. They are generally characterised as multifactorial polygenetic disease patterns and still represent the main cause of death in western industrialised countries.
The common goal of all the subprojects brought together in CRC 612 was to investigate and influence molecular regulatory circuits that are the basis for normal and pathologically altered myocardial and vascular function and contribute to or significantly determine the expression of a specific cardiovascular phenotype.
Spokesperson: Prof. Dr. med. J. Schrader,
Institute for Cardiovascular Physiology
Duration: 2002 to 2012
Ageing is one of the least understood phenomena in human biology. It is generally accepted that ageing results from the sum of various mechanisms that limit the lifespan of biological systems (cells, organs, organisms) and which are only partially known. Therefore, causal concepts to control the medical problems of old age are lacking. By elucidating ageing mechanisms at the molecular level, CRC 728 has contributed to solving this problem.
Spokesperson: Prof. Dr. Jean Krutmann,
IUF Leibniz Institute for Environmental Medicine Research
Duration: 2007 to 2012
The common goal of all subprojects involved in CRC 575 was to use basic scientific methods to gain new insights into the function of the normal liver and to investigate the molecular mechanisms that lead to clinically relevant disorders in the wake of liver damage. The knowledge gained should provide a basis for the development of new therapeutic strategies for liver diseases.
Spokesperson: Prof. Dr. Dieter Häussinger,
Department of Gastroenterology, Hepatology and Infectology
Duration: 2001 to 2011
The Collaborative Research Centre (CRC) 663 of the German Research Foundation "Molecular Response after Electronic Excitation" was a research network of the HHU Düsseldorf, the Max Planck Institute for Bioinorganic Chemistry in Mülheim and the Max Planck Institute for Coal Research in Mülheim. CRC 663 began its work in July 2005. The spokesperson was Prof. Dr. Christel M. Marian (Institute for Theoretical Chemistry and Computational Chemistry at HHU).
The research activities focus on photo-induced processes in complex systems. The primary goal is to understand the intra- and intermolecular interactions that occur on a microscopic level as a result of exposure to photons and, above all, to identify the electronic intermediate states and reaction pathways of the molecules involved: for the far-reaching benefit of developments in biochemistry, materials science and medicine, for example in the development of photostable dyes or endogenous sun protection.
Spokesperson: Prof. Dr. Christel M. Marian,
Institute for Theoretical Chemistry and Computational Chemistry
Duration: 2005 to 2010